Promethazine HCl and Codeine Phosphate Oral Remedy should be employed with warning in sufferers with intense impairment of renal perform, and clients need to be monitored carefully for respiratory despair, sedation, and hypotension.
In general, dose variety for an elderly patient must be cautious, generally starting off for the small conclude of the dosing variety, reflecting the better frequency of lowered hepatic, renal or cardiac purpose, and of concomitant disorder or other drug therapy.
Test your neighborhood drug retailer and clinics for consider-back places. You can even Test the DEA Internet site for locations. Here's the url on the FDA Secure disposal of medicines Web page:
Consume plenty of fluids when you are utilizing this medication Except if otherwise directed by your medical doctor. The fluid can help loosen the mucus in the lungs.
Narcotic analgesics may perhaps cause nausea and vomiting by stimulating the chemoreceptor bring about zone (CTZ); nonetheless, they also depress the vomiting Centre, so that subsequent doses are not likely to supply vomiting. Nausea is negligible right after common oral doses of codeine.
Even though it can help Many of us, this medication features a hazard for abuse and should occasionally lead to dependancy. This hazard could possibly be larger For those who have a substance use condition (such as overuse of or addiction to medicines/Liquor).
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The phosphate salt of codeine takes place as white, needle-formed crystals or white crystalline powder. Codeine phosphate is freely soluble in drinking water and marginally soluble in alcohol. The molecular body weight is 406.37. Its molecular method is C18H21NO3•H3PO4 • ½ H2O, and it has the subsequent chemical structure.
Promethazine HCl and Codeine Phosphate Oral Resolution need to be utilized with caution in people with bone- marrow despair. Leukopenia and agranulocytosis are actually described, typically when promethazine has become Employed in association with other recognised marrow-toxic agents.
The risk for significant respiration troubles is larger when You begin this medication, or if you are taking the incorrect dose or acquire much more of the medication than prescribed. Taking this medication with alcohol or other medication that might cause drowsiness or breathing challenges may perhaps lead to pretty critical Unwanted side effects, such as Demise. Also, other medications can influence the removal of the item from the body, which can impact how it works.
Take this medication specifically as prescribed to decrease the chance of dependancy. Request your medical professional or pharmacist For additional details.
Do not use this products to take care of chilly indications in kids young than six decades Except if especially directed by the medical doctor. Some products (including very long-acting tablets/capsules) aren't advised for use in little ones younger than 12 many years. Question your doctor or pharmacist For additional specifics about using your merchandise safely.These items tend not to heal or shorten the duration from the frequent cold and may induce serious Unintended effects. To decrease the chance for critical side effects, meticulously abide by all dosage directions. Tend not to use this products for making a child sleepy. Usually do not give other cough-and-chilly medication that might include the identical or comparable ingredients (see also Drug Promethazine codeine syrup Interactions segment). Ask the health practitioner or pharmacist about other methods To alleviate cough and chilly indications (which include consuming more than enough fluids, utilizing a humidifier or saline nose drops/spray).
Codeine is known to get substantially excreted from the kidney, and the risk of adverse reactions to this drug could be bigger in clients with impaired renal function.
The therapy of overdosage with promethazine and codeine is actually symptomatic and supportive. Only in scenarios of utmost overdosage or person sensitivity do very important signs like respiration, pulse, blood pressure, temperature, and EKG should be monitored. Activated charcoal orally or by lavage may be specified, or sodium or magnesium sulfate orally as being a cathartic. Notice must be specified into the reestablishment of sufficient respiratory exchange by way of provision of the patent airway and institution of assisted or controlled air flow.